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. 2016 Jun 22;6:28395. doi: 10.1038/srep28395

Figure 4. Proteo-β-glucan from Maitake (PGM) mediated the antidepressant effect through its receptor Dectin-1.

Figure 4

(A) The PGM treatments increased its receptor Dectin-1 levels in the prefrontal cortex (PFC) after 5 days of treatment. CD-1 mice were i.p. injected with a low dose of PGM (5 mg/kg/day, PGM-L), a medium dose of PGM (8 mg/kg/day, PGM-M), a high dose of PGM (12.5 mg/kg/day, PGM-H), imipramine (15 mg/kg/day, IMI) or saline (Sal) for 5 days. Western blot analyses of the proteins from the PFC were performed with anti-Dectin-1 antibodies. (B) Dectin-1 receptor specific blocking reagent Laminarin (Lam) was able to block the antidepressant effect of PGM in the tail suspension test (TST). The number (N) of mice per group is indicated in each individual graph. Any experimental data value greater than mean plus 2 × standard deviations (SDs) from a group was considered an outlier and was not considered in the analysis. Data were analysed by one-way ANOVA and presented as the mean ± SE (post hoc Tukey’s Test, *p < 0.05, **p < 0.01, ***p < 0.001).