Figure 9. The α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor-specific antagonist GYKI 52466 (GYKI) significantly blocked the proteo-β-glucan from Maitake (PGM)-induced an antidepressant effect in the tail suspension test (TST).

CD-1 mice were i.p. injected with a medium dose of PGM (8 mg/kg) or saline (Sal) for 60 minutes. GYKI (10 mg/kg) or vehicle (Veh) was administered 30 minutes prior to behavioural testing. Then, the CD-1 mice were subjected to the TST. The immobility time was determined. The number (N) of mice per group is indicated in each individual graph. Data were analysed by one-way ANOVA and presented as the mean ± SE (post hoc Tukey’s test, *p < 0.05, **p < 0.01, ***p < 0.001).