Table 1.
Top genes show statistically significant changes after tobacco exposure versus control at 24 weeks.
| Affyid | Symbol | Name | Entrez | LogFC | AveExpr | Adj.P. Val | B | Comments | |
|---|---|---|---|---|---|---|---|---|---|
| 4687 | 10390211 | Igf2bp1 | Insulin-like growth factor 2 mRNA binding protein 1 | 140486 | −0.62 | 7.69 | 0.02 | 5.41 | RNA-binding, IFG signaling |
| 19465 | 10527940 | Cdk14 | Cyclin-dependent kinase 14 | 18647 | −0.96 | 8.35 | 0.02 | 4.62 | Regulation of mitosis and meiosis |
| 9672 | 10435948 | Ccdc80 | Coiled-coil domain containing 80 | 67896 | −0.71 | 6.23 | 0.02 | 4.37 | Glucose, lipid metabolism; peroxisomal |
| 4647 | 10389759 | Ankfn1 | Ankyrin-repeat and fibronectin type III | 382543 | −0.56 | 5.52 | 0.02 | 4.22 | Membrane protein |
| 23915 | 10566201 | Olfr589 | Olfactory receptor (OR)589 | 259054 | −0.47 | 5.05 | 0.02 | 4.16 | OR receptors may function as a chemosensing receptors in mouse germ cells and sperm |
| 18835 | 10521498 | Crmp1 | Collapsin response mediator protein 1 | 12933 | −0.73 | 7.45 | 0.02 | 3.76 | Expressed in spermatids |
| 18692 | 10519811 | Speer8-ps1 | Spermatogenesis associated glutamate (E) | 74062 | −1.48 | 7.82 | 0.02 | 3.66 | A trascribed pseudogene; testis-specific. |
| 8111 | 10420286 | Gzmn | Granzyme N | 245839 | 0.4 | 9.77 | 0.02 | 3.3 | Expressed in spermatids and spermatocytes, may be involved in spermatogenesis |
| 4631 | 10389639 | Lpo | Lactoperoxidase | 76113 | −0.54 | 6.34 | 0.03 | 3.07 | May have a role in oxidative stress in testicular cell mitochnodria |
| 14980 | 10485372 | Rag1 | Recombination activating gene 1 | 19373 | −0.45 | 6.03 | 0.03 | 2.97 | Immunoglobulin; may also be produced by testicular cells |
LogFC: log2 fold change for that gene. A positive value indicates up-regulation of a gene, a negative value indicates down-regulation; aveExpr: average expression value for that gene across all the arrays; adj.P.Val: adjusted p-value (a p-value adjusted for multiple testing by Benjamini–Hochberg method); B: the log odds that the gene is differentially expressed. A B-statistic of zero corresponds to a 50–50 chance that the gene is differentially expressed.