Fig. 10.

Frontal sections through the embryonic telencephalon of different mouse embryos (E16.5), at the level of the posterior medial amygdala (MePD, MePV), hybridized for Lhx6 or Shh, or immunostained for NPY or SOM. Based on the distinct gene expression profile, MePD and MePV appear to originate in different parts of the subpallium. The MePD shows strong expression of Lhx6 but lacks Shh expression, and appears to be an AEP derivative. On the other hand, the MePV (its central part) is poor in Lhx6 but shows strong expression of Shh, and appears to derive at least partially from the POC (although another subset of cells in this nucleus may derive from the diencephalon/hypothalamus). The superficial part of MePV does not express subpallial marker genes, and apparently originate in the ventral pallium. Note the group of SOM+ cells (possibly immigrant cells of AEP origin) in the central amygdala. See text for more details. For abbreviations, see list. Scale bar = 200 µm. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]