TABLE 1.
Genetic and Cellular Features of Mouse Telencephalic Subdivisions at E12.5–E16.5
| A: E12.5 | |||||||
|---|---|---|---|---|---|---|---|
| Lhx9 | Dlx5 | Nkx2.1 | Lhx6 | Lhx7/8 | Shh | Gbx1 | |
| VP | 3 svz, m | 0 | 0 | 0 | 0 | 0 | 0 |
| LGE | 0 | 3 svz, m | 0 | 0 | 0 | 0 | 0 |
| MGE | 0 | 3 svz, m | 3 vz, svz, m | 3 svz, m | 3 svz, m | 11 svz | 11 svz, m |
| Septo-AEP | 0 | 3 svz, m | 3 vz, svz, m | 3 svz | 3 svz | 11 svz | 11 svz, m |
| POC | 0 | 3 svz, m | 3 vz, svz, m | 3 svz | 3 svz | 3 vz, svz | 2 svz, m |
| B: E14.5 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Lhx9 | Dlx5 | Nkx2.1 | Lhx6 | Lhx7/8 | Shh | Gbx1 | SOM | CALB | CHAT | |
| VP | 3 | 0 | 0 | 11 | 0 | 0 | 0 | 0–11 | 1–21 | 0 |
| LGE | 0 | 3 | 11 | 11 | 11 | 0 | 0 | 0–11 | 1–21 | 0 |
| MGE | 0 | 3 | 3 | 3 | 3 | 11 | 11 | 0 | 1–2 | 0 |
| Septo-AEP | 0 | 3 | 3 | 3 | 3 | 11 | 11 | 3 | 3 | 11 |
| POC | 0 | 3 | 3 | 3 | 3 | 3 | 3 | 0 | 1–2 | 3 |
| C: E16.5 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Lhx9 | Dlx5 | Nkx2.1 | Lhx6 | Lhx7/8 | Shh | SOM | CALB | CHAT | |
| VP | 3 | 0 | 0 | 11 | 0 | 0 | 11 | 21,2 | 0 |
| LGE | 0 | 3 | 11 | 11 | 11 | 0 | 11 | 1–21,2 | 11 |
| MGE | 0 | 1 | 3 | 3 | 1–21 | 11 | 0 | 1–21,3 | 11 |
| Pallidal Septum | 0 | 1–2 | 2–3 | 1–3 | 2–3 | 1 1 | 0 | 1–23 | 11 |
| AEP | 1 | 1–2 | 3 | 1–2 1 | 11 | 3 | 34 | 11 | |
| POC | 0 | 1 | 2 | 2 | 3 | 3 | 0 | 1–2 | 3 |
m, mantle; svz, subventricular zone; v, ventricular zone.
0, no expression; 1, weak expression; 2, moderate expression; 3, strong expression.
1
Expression is related completely or partially to immigrant cells.
2
Only mantle.
3
Mostly periventricular.
4
Periventricular + mantle.