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. 2016 Jun 22;7:168. doi: 10.3389/fphar.2016.00168

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Copyright © 2016 Kandimalla, Dash, Kalita, Choudhury, Malampati, Kalita and Kotoky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of drug treatment on liver histopathology of CCl₄ intoxicated rats. (A) Liver of control rat with no CCl₄ treatment showing normal hepatocytes with no inflammatory cell infiltrate; x10. (B) Liver of rat treated with CCl4 showing formation of bridging necrosis with chronic inflammatory cells; x10. (C) Liver of rat treated with CCl4 and 100 mg/kg silymarin showing normal hepatocytes with no inflammation and necrosis; x10. (D) Liver of rat treated with CCl4 and 400 mg/kg of ARBME showing mild periportal inflammation and no necrosis; x10. (E) Liver of rat treated with CCl4 and 100 mg/kg ARBWF showing absence of inflammatory cells or necrosis; x10. ARBME, A. reticulata bark methanol extract; ARBWF, A. reticulata bark water fraction.