Table 2.
Effect of different drug treatment on serum and liver enzyme levels of CCl4 intoxicated rats.
| Group no. | Group | Serum levels of |
Liver levels of |
|||||
|---|---|---|---|---|---|---|---|---|
| AST (IU/l) | ALT (IU/l) | ALP (IU/l) | LDH (U/l) | SOD (U/ml) | CAT (nmol/min/ml) | TBARS (nmol/g tissue) | ||
| 1 | Control | 41.6 ± 2.8 | 38.3 ± 2.4 | 94.5 ± 3.2 | 436.8 ± 15.4 | 9.8 ± 1.1 | 5.2 ± 0.8 | 158.5 ± 8.7 |
| 2 | CCl4 treatment (1.5 ml/kg) | 124.2 ± 6.1$$$ | 96.7 ± 5.8$$$ | 197.5 ± 9.7$$$ | 1022.9 ± 29.2$$$ | 1.9 ± 0.4$$$ | 0.8 ± 0.1$$$ | 342.8 ± 12.6$$$ |
| 3 | Silymarin (100 mg/kg) + CCl4 (1.5 ml/kg) | 52.8 ± 4.4∗∗∗ | 44.6 ± 3.5∗∗∗ | 108.2 ± 7.8∗∗∗ | 471.4 ± 20.6∗∗∗ | 7.7 ± 0.8∗∗∗ | 4.6 ± 0.5∗∗∗ | 171.8 ± 9.4∗∗∗ |
| 4 | ARBME 200 mg/kg + CCl4 (1.5 ml/kg) | 72.7 ± 5.3∗∗∗ | 59.9 ± 3.8∗∗∗ | 132.4 ± 7.2∗∗∗ | 563.8 ± 18.5∗∗∗ | 3.8 ± 0.7∗∗∗ | 3.2 ± 0.4∗∗ | 213.4 ± 11.8∗∗∗ |
| 5 | ARBME 400 mg/kg + CCl4 (1.5 ml/kg) | 63.4 ± 4.8∗∗∗ | 53.4 ± 4.1∗∗∗ | 121.8 ± 9.6∗∗∗ | 509.4 ± 16.6∗∗∗ | 5.6 ± 1.1∗∗∗ | 3.9 ± 0.6∗∗∗ | 186.1 ± 8.6∗∗∗ |
| 6 | ARBWF 50 mg/kg + CCl4 (1.5 ml/kg) | 67.6 ± 5.4∗∗∗ | 53.9 ± 4.7∗∗∗ | 126.9 ± 8.5∗∗∗ | 530.7 ± 19.2∗∗∗ | 5.1 ± 0.9∗∗∗ | 3.8 ± 0.4∗∗∗ | 194.5 ± 9.7∗∗∗ |
| 7 | ARBWF 100 mg/kg + CCl4 (1.5 ml/kg) | 57.3 ± 3.9∗∗∗ | 45.1 ± 3.6∗∗∗ | 111.2 ± 8.8∗∗∗ | 494.3 ± 21.2∗∗∗ | 6.8 ± 0.9∗∗∗ | 4.5 ± 0.7∗∗∗ | 178.6 ± 10.5∗∗∗ |
All the results were expressed in mean ± SD (n = 6). $$$P < 0.001 in comparison of CCl4 alone treated animals with normal animals. ∗∗∗P < 0.001 and ∗∗P < 0.01 in comparison of drug treated animals with CCl4 alone treated animals. ARBME, A. reticulata bark methanol extract; ARBWF, A. reticulata bark water fraction.