Figure 1. Pneumonia severity as measured by bacterial burden correlates with plasma leptin levels in K. pneumoniae–infected lean and obese mice.

(A) Lung bacterial CFU were determined at 48 hours after K. pneumoniae infection in lean (10% fat diet) and diet-induced obese (60% fat diet) mice. In addition, (B) lung CFU was compared with mouse weight and (C) plasma leptin levels by linear regression. n = 11 (10% diet) and n = 9 (60% diet) animals. Black circles indicate lean mice; black squares indicate obese mice. Dashed lines indicate 95% CI. ***P ≤ 0.001 as determined by an unpaired Student’s t test (2-tailed).