Figure 1.

The predicted distribution of the intrinsically disordered regions in 2 major nucleolar proteins, FIB-1/fibrillarin (A and B) and Nopp140/Nolc1 (C and D), in C. elegans (A and C, indicated as Ce-Fib-1 and Ce-Nopp140) and human (B and D, indicated as Hsa-Fibrillarin and Hsa-Nolc1). Results reveal that the thermodynamic patterns and tendencies between the 2 homologous gene sets are conserved. Higher PONDR scores reflect a stronger tendency toward intrinsic structural disorder. Notably, the central region of Nopp140, with a tandem pair of acidic and basic regions,³⁰ significantly coincides with the low-complexity region. Scoring was based on the VX-LT algorithm. The sequence prediction analyses were determined by PONDR (www.pondr.com).