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. 2016 Mar 30;7(2):126–131. doi: 10.1080/19491034.2016.1169352

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Mechanism for a relay between TREX-2, Mediator, and Pol II. Model depicts the putative overall topology of the NPC-associated TREX-2 complex and its interaction with Mediator. Mediator cartoon follows the outline of the yeast Mediator cryo-EM structure. TREX-2 is subdivided into an NPC-anchor domain (upper part) and a PCI domain part (lower part). (1) Docking to Mediator involves a conserved pair of basic Sac3 residues (red sticks) and the Med31 submodule. (2) TREX-2 regulates Cdk8 kinase module association. (3) TREX-2 impacts on RNA Pol II CTD Ser5 phosphorylation (S5; yellow). (4) TREX-2 also influences mRNA export via the same PCI surface used for interacting with Mediator. Other mRNA adaptor/export proteins are indicated. Transition between Pol II initiation and early elongation is shown. Act : transcription activator; CBC: Cap Binding Complex.