Figure 4.

Chromosomes are spatially organized within the nucleus. The NE is blue, and the nuclear lamina is the orange structure lining the nucleoplasmic face of the NE. NPCs are black and inserted into the NE. Each chromosome is outlined in brown and is composed of multiple different TADs that are depicted with different colors. An example of the type of chromatin interaction occurring within a TAD is shown within the red oval. LAD interactions of chromatin with the nuclear lamina are also depicted. It is easy to imagine how a change in nuclear volume and/or shape might impact this chromosomal organization.