Table 1. Structure and activity of BACE2 inhibitors.

Compound	BACE2 Ki (nM)	BACE1 Ki (nM)
2	14.6 ± 2.9	45.6 ± 15.3
3	0.031 ± 0.021	5244 ± 1711
13	80.5 ± 4.7	1812 ± 194
14	182.8 ± 22.7	731 ± 65
15	1.0 ± 0.15	1657 ± 44.6
18	14.02 ± 6.6	837.3 ± 25.1
20	0.038 ± 0.014	563.5 ± 18.5