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A. Left, Topology diagram of a 6TM spanning Kv α subunit with voltage sensing domain (VSD) and pore domain highlighted. Right, 1TM topology of a KCNE subunit. Ext, extracellular; Int, intracellular.
B. 4:2 α:β stoichiometry of a KCNQ1-KCNE1 complex.
C. Sequence alignment of the KCNE gene family. Transmembrane (TM) domain boxed; highly conserved residues/features indicated with gray shading.
