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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Gene. 2015 Sep 26;576(1 Pt 1):1–13. doi: 10.1016/j.gene.2015.09.059

Figure 3. Mechanisms of KCNE1 and KCNE3 control of KCNQ1 gating and conductance.

Figure 3

A. Topology diagrams of KCNQ1 with KCNE1 (upper) and KCNE3 (lower) showing residues (numbered where specific residues have been identified as particularly important) and domains identified as being influential in control of KCNQ1 gating by the KCNEs. Arrows: red, KCNE1 or 3 control of KCNQ1 activation; yellow, KCNE1 control of deactivation; orange, KCNE1 control of inactivation; pink, KCNE1 control of conductance; purple, inter-domain interactions within KCNQ1 that are affected by KCNE1; dashed purple, KCNQ1 outer vestibule/selectivity filter flexibility; dashed gray, physical proximity and/or interaction without major functional effects. “−” = acidic residue, “+” = basic residue. Citations appear in main text.

B. Cartoon of possible orientations with respect to KCNQ1 (blue), based on evidence summarized in panel A, of KCNE1 (upper) and KCNE3 (lower) at resting membrane potential. S6′ = the S6 of an adjoining KCNQ1 α subunit. KCNEs are depicted as semi-transparent to avoid concealing KCNQ1 features.