Table 1. Summary of main effects of KCNE1 and KCNE3 on Kv α subunits.
See main text for expanded description of effects.
| Kv α subunit | Effects of KCNE1 | Effects of KCNE3 |
|---|---|---|
| KCNQ1 | Slows activation, strongly increases peak current in oocytes, CHO and HEK cells, and cardiac myocytes.12,13 | Instantaneous activation, small increase in peak current in oocytes and CHO cells.17,33 |
| KCNQ4 | Mild upregulation in Xenopus oocytes.67 | Inhibits in Xenopus oocytes.17,78 |
| KCNQ5 | Slows activation, increases peak current by decreasing inward rectification in HEK, oocytes. 77 | Inhibits in HEK cells and in Xenopus oocytes. 77 |
| hERG | Doubles current density in CHO cells.61 | Strongly inhibits in Xenopus oocytes.8 |
| Kv1.1 | No effect in CHO cells.69,70 | ? |
| Kv1.1-Kv1.4 | Increases current density 2-fold in CHO cells.69,70 | ? |
| Kv1.4 | Traps in ER/Golgi in CHO cells. 69,70 | ? |
| Kv2.1 | Slows activation/deactivation in CHO cells.57 | Slowed activation/deactivation in CHO cells.76 |
| Kv3.1 | Strongly slows activation/deactivation, accelerates inactivation in CHO cells.71 | Weakly slows activation/deactivation, accelerates inactivation in CHO cells.71 |
| Kv3.1-Kv3.2 | Strongly slows activation/deactivation, accelerates inactivation in CHO cells.71 | Weakly slows activation/deactivation, accelerates inactivation in CHO cells.71 |
| Kv3.1-Kv3.4 | Attenuates inactivation by “mopping” up homomeric Kv3.4 in CHO cells.69,70 | ? |
| Kv3.2 | Strongly slows activation/deactivation, accelerates inactivation in CHO cells.71 | Weakly slows activation/deactivation, accelerates inactivation in CHO cells.71 |
| Kv3.3 | Inhibits, probably by trapping in ER/Golgi in CHO cells.69,70 | ? |
| Kv3.4 | Traps in ER/Golgi in CHO cells. 69,70 | Augments activity, left-shifts voltage dependence in CHO cells.65 |
| Kv4.2 | No effect (with α,β staggered injection) in Xenopus oocytes.73 | Inhibits in CHO cells and In SGNs.72 |
| Kv4.3 | Slows gating, increases current in HEK cells.75 | Inhibits in CHO cells.74 |
| Kv4.3-KChIP2 | Accelerates activation. Mildly speeds, slows recovery of, and left-shifts steady state inactivation; all in CHO cells.76 | Accelerates activation. Strongly speeds, slows recovery of, and left-shifts steady state inactivation; all in CHO cells.76 |
| Kv12.2 | Inhibits in Xenopus oocytes.67 | Inhibits Xenopus oocytes.67 |