Table 3.
Diagnostic accuracy of faecal calprotectin for colorectal cancer, significant neoplasia, and organic enteric disease
| FC, mcg/g | NPV | PPV | Sensitivity | Specificity | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
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| Median | IQR | Value | 95% CI | Value | 95% CI | Value | 95% CI | Value | 95% CI | |
| Neoplasia | ||||||||||
| Cancer | 227 | 94.5 to 496 | 98.6 | 95.7 to 99.6 | 8.7 | 6.3 to 11.9 | 92.7 | 79 to 98 | 35.2 | 31.5 to 39.2 |
| Cancer and polyps | 189.5 | 88 to 494 | 97.2 | 93.8 to 98.9 | 15.6 | 12.4 to 19.4 | 91.9 | 82.6 to 96.7 | 36.4 | 32.5 to 40.5 |
| Organic enteric disease | 232 | 79 to 580 | 89.4 | 84.3 to 93 | 32.7 | 28.4 to 37.4 | 86.1 | 79.7 to 90.8 | 39.8 | 35.4 to 44.3 |
IFC = faecal calprotectin. QR =interquartile range. NPV = negative predictive value. PPV = positive predictive value.