Fig 10. Summary of the functionally important positions reported in the literature and predicted in this work highlighted in the Class A serine beta-lactamase domain (1shvA00).

In both (a) and (b) the omega loop has been shaded black. (a) In this figure, the catalytic residues are shown as red sticks, ASSP predicted residues are shown in green, SSPA predicted residues in magenta. The residues predicted by FunFHMMer and cited in the literature are shown in blue and those not yet cited are shown in yellow. (b) In this figure, any predicted residues having experimental validation are shown in red along with the catalytic residues which are shown as sticks. Any predicted residue in this work that lie within 5Å radius of any experimentally-validated residue are shown as orange. Other residues outside the 5Å radius are coloured according to the colour scheme in (a).