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. Author manuscript; available in PMC: 2016 Jun 22.
Published in final edited form as: J Cancer Stem Cell Res. 2015 Feb 27;3:e1003. doi: 10.14343/JCSCR.2015.3e1003

Figure 6. SHH pathway in CD133+ GBM cells in TMZ resistance.

Figure 6

PTCH1, Gli1 and MDR1 were knocked down with targeted siRNA in U87 and T98G CD133+ cells. The efficiency of the knockdowns was confirmed by real time PCR (left). Knock-down cells were then treated with 200 μM TMZ. After 72 h, cell viability was assayed by CytoTox 96® LDH release (center/right). The results are shown as the mean ± SD, n ¼ 4.