Table 1. Published (English-language) cases of infective endocarditis due to Serratia spp. since 1980.
Study/ Year/Ref | Location | Age | Risk factor(s) | Organism | Valve(s) | Antimicrobial therapy | Surgery | Outcome |
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Hyams/ 1981/22 | USA | 7 years | Extensive third-degree burns, central venous catheter | S. marcescens | TV | Cefotaxime × 6 weeks | None | Survived |
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Hobbs/ 1982/23 | USA | 56 years | Diabetes mellitus, ESRD, intra-abdominal surgery | S. marcescens | TV, PV, AV, MV | Ampicillin + tobramycin | None | Died |
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Berkowitz/1983/24 | South Africa | 14 years | Mitral valve repair for rheumatic mitral regurgitation | S. marcescens | MV | Ceftazidime × 6 weeks | Mitral valve replacement x2 | Survived |
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Ena/ 1991/25 | Spain | 29 years | IVDU | S. marcescens | AV, MV, TV? | Ciprofloxacin × 4 weeks | None | Survived |
56 years | Post-sternotomy mediastinitis | S. liquefaciens | AV (prosthetic) | Ciprofloxacin × 4 weeks | None | Survived | ||
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Korner/ 1994/26 | UK | 50 years | Non-Hodgkin's lymphoma, central venous catheter | S. marcescens | AV, MV | Azlocillin + gentamicin × 6 weeks | None | Survived |
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Riberi/ 1997/27 | France | NS | NS | Serratia spp. | AV | NS | Aortic valve replacement | NS |
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Pearlman/ 1998/28 | USA | 27 weeks | Prematurity | S. marcescens | Right ventricle | Cefotaxime + gentamicin | None | Died |
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Mossad/ 2000/29 | USA | 55 years | Short gut syndrome, central venous catheter with suppurative thrombophlebitis | S. liquefaciens | Right atrium | Ceftriaxone | None | Survived |
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Chuang/ 2007/30 | Taiwan | 41 years | IVDU, cirrhosis | S. liquefaciens | AV | Imipenem-cilastatin | None | Died |
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Morpeth/ 2007/21 | Multi-national | NS (n=4) | NS | NS | NS | β-lactam + fluoroquinolone (2/4), β-lactam + aminoglycoside (2/4) | Yes, details NS | Survived |
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Yang/ 2007/31 | China | 11 years | Intracardiac foreign body | S. marcescens | Right and left atria | Cefminox + etimicin | Resection of foreign body | Survived |
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Baggish/ 2007/32 | USA | 43 years | Splenectomy | S. marcescens | MV | Cefepime × 6 weeks + gentamicin × 2 weeks | None | Survived |
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De Silva/ 2009/33 | USA | 67 years | Pacemaker | S. marcescens | Pacing wire | Meropenem + gentamicin, then ciprofloxacin × 2 weeks | Explantation of pace-maker | Survived |
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Hadano/ 2012/34 | Japan | 85 years | Diabetes mellitus | S. marcescens | MV | Ceftazidime + gentamicin | None | Died |
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Lyall/2013/35 | UK | 65 years | Post-Bentall procedure | S. marcescens | AV (prosthetic) | Meropenem + ciprofloxacin + gentamicin | NS | Survived |
Abbreviations: ESRD = end-stage renal disease, IVDU = intravenous drug use, TV = tricuspid valve, PV = pulmonic valve, AV = aortic valve, MV = mitral valve, NS = not specified