Figure 3.

Collagen densification induces in local fibril alignment and bundling. a) Measurements of mean fibril thickness, maximum fibril thickness, and fibril area fraction were increased in density compared to control regions. Letters indicate statistically significant groups (p<0.004). b) Distribution of fibril thicknesses varied with strain magnitude and density region (high vs low). c) Qualitative analysis reveals fibril bundling in high-density regions (scale bar: 3000×=15μm, 12,000×=5μm, 50,000×=1μm). Dashed boxes indicate area of subsequent zoom.