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. 2016 Jun 22;11(6):e0157641. doi: 10.1371/journal.pone.0157641

Fig 7. Schematic for the ATRP synthesis of a TEMPO-terminated poly(DMAA) polymer.

Fig 7

The stable free-radical nitroxide, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO˙) was added to polymer chains to investigate its effects as a cytoprotective antioxidant attached to human red blood cells (1). NHS functional group attachment facilitates cell attachment via covalent amide bond formation with surface proteins (2). Polymer chains lacking NHS functionality were used as a control for cell surface binding (3). The average molecular weight of polymer chains was approximately 6.2kDa.