Figure 5. Loss of GCN2 accelerates B6J-Gtpbp2^nmf205-/- cerebellar degeneration.

(A) Hematoxylin and eosin- stained sagittal sections of B6J.Gcn2^-/-, B6J-Gtpbp2^nmf205-/- (B6J-nmf205^-/-), B6J-Gtpbp2^nmf205-/-; Gcn2^-/- and B6J cerebella. Higher-magnification images of cerebellar lobule IX and lobule VI are shown on lower panels. Scale bars, 1 mm (top row), and 50 μm (bottom two rows). (B) Numbers of granule cells (n=3 mice/genotype). Means ± SEM are shown. *p<0.05, **p<0.01, and ***p< 0.001 (one-way ANOVA).

DOI: http://dx.doi.org/10.7554/eLife.14295.025