Figure 6.

Emx1 lineage cells actively proliferate in postnatal SVZ and participate in adult neurogenesis of OB cells. A, Many EGFP⁺ cells in P0 SVZ express Ki67, a proliferation marker. A′, Higher magnification of A. B, EGFP⁺ cells in adult SVZ continue to proliferate. B′, Higher magnification of a representative area shown in B. BrdU was injected once in the adult, and animals were killed 15 d later. C, Examples of EGFP⁺ cells in granule cell layer labeled with BrdU, indicating that Emx1 lineage participates in adult neurogenesis. D, Example of an EGFP⁺ periglomerular cell labeled with BrdU. Arrows indicate cells double labeled with Ki67 and EGFP (A, B) or BrdU and EGFP (C, D). Scale bars: A, 50 μm; A′, B′, 20 μm; B, 100 μm; C, D, 30 μm.