Table 1.
Effects of MeHg or MeHg–Cys complex exposure on respiratory rates of rat liver slices.
Rate 1
|
Rate 2
|
Rate 3
|
|
---|---|---|---|
Respiration of slices (nmol O2/mL/min) | Respiration with succ. (nmol O2/mL/min) | Respiration with MeHg or MeHg–Cys (nmol O2/mL/min) | |
Control | 2.27±0.22 | 6.59±0.37 | 5.32±0.47 |
MeHg | 2.26±0.47 | 6.09±0.32 | 3.49±0.52a,b |
MeHg–Cys | 2.10±0.38 | 5.97±0.18 | 2.34±0.05a,b,c |
With methionine | |||
Control | 2.42±0.27 | 6.17±0.98 | 5.57±0.75 |
MeHg | 2.38±0.10 | 6.55±0.53 | 5.45±0.35d |
MeHg–Cys | 2.37±0.18 | 6.10±0.34 | 3.43±0.26a,b,d |
Slices were pre-treated for 15 min with Met (250 μM) and after exposed for 30 min to MeHg (25 μM) or MeHg–Cys complex (25 μM each).
Indicates p<0.05, rate 3 compared to 2.
Indicates p<0.05 from control.
Indicates p<0.05 from MeHg.
Indicates p<0.05 from MeHg–Cys complex, n=5 mean±S.E).