Fig. 1.

CVR metrics used to characterize future WMHs. (A) T1-weighted images from a subject with diffuse periventricular and deep WMHs. (B) Steady-state CVR (ssCVR) map in the same subject showing reduced CVR in areas of WMHs. (C) Tau map demonstrating slower vascular responses to carbon dioxide in regions of WMHs. (D) FLAIR images showing WMHs on the baseline scan. Two color scales are used to represent regions with positive ssCVR (red to green) and negative ssCVR (light blue to purple). (E) FLAIR images showing WMHs on the follow-up scan. (F) WMHs identified on the baseline scan are highlighted in yellow. (G) WMHs identified on baseline are highlighted in yellow whereas new hyperintensities identified on follow-up are highlighted in red. CVR values are in units of % BOLD/mmHg. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)