Table 2.
Comparison of CVR metrics in regions of NAWM that progressed to WMH against other tissue types. Values are given as mean (SD). ssCVR comparisons were made using Friedman test with Dunn's correction for multiple comparison while comparisons involving τ were made using repeated measures one-way ANOVA with Bonferroni correction.
| Grey matter | All NAWM | Pre-existing WMH | Baseline NAWM that progressed to WMH | |
|---|---|---|---|---|
| ssCVR [% BOLD/mmHg] | 0.32 (0.07) |
0.17 (0.06)⁎ |
0.11 (0.06)⁎, + |
0.09 (0.08)⁎, + |
| τ [s] | 23.50 (7.47) |
35.62 (9.30)⁎ |
50.25 (11.52)⁎, + |
46.02 (15.86)⁎, + |
⁎
Denotes significance vs. grey matter ( P < 0.01).
+
Denotes significance vs. all NAWM (P < 0.01). No significant differences were observed between pre-existing WMH and NAWM that progressed to WMHs.