Table 4.

Premature menopause, Time from menopause and risk of Fibrosis: subgroup analysis in patients with borderline NASH or NASH

	Univariate COR(95%CI), p-value	Model 1 COR(95%CI), p-value	Model 2 COR(95%CI), p-value
Premature menopause
No	-	-	-
Yes	1.2 [0.9–1.8], p=0.27	1.6 [1.1–2.4], p=0.02	1.4 [0.9–2.1], p=0.11
Time from menopause, for 5 years	1.2 [1.1–1.4], p<0.0001	1.2 [1.0–1.3], p=0.01	1.1 [1.0–1.3], p=0.05

Model 1: Adjusted for age at enrollment, race, waist circumference/BMI, current smoking/alcohol use, hypertension, diabetes/IFG, HOMA-IR, and HRT.

Model 2: Adjusted for the above covariates, hepatocyte ballooning grades, and portal inflammation grades.