Table 1.
Clustering of genes in each Endocrine System Development and Function GO category in each experimental genotype.
| Endocrine System Development and Function Annotation | p-value | Molecules | |
|---|---|---|---|
| Pdx1Lacz/+ | migration of beta islet cells | 4.38E-03 | Vtn |
| transmembrane potential of beta islet cells | 4.38E-03 | Kcnj11 | |
| development of enteroendocrine cells | 8.74E-03 | Atoh1 | |
| replication of beta islet cells | 1.31E-02 | Reg1a | |
| formation of parathyroid gland | 1.74E-02 | Aldh1a7 | |
| glucuronidation of beta-estradiol | 1.74E-02 | Nr1i2 | |
| differentiation of beta islet cells | 2.17E-02 | Slc2a2 | |
| Oc1+/− | glucose tolerance | 2.34E-04 | ABCB4, ATF4, C19orf10, CBL, CCKBR, CYP2J2, FFAR3, Fxyd2, GRB10, HNF4A, HTR2C, HTR3A, HYOU1, IAPP, INS, IRS2, KLF15, Mir-802, NR0B2, NR1H4, PCBD1, RBP1, SERP1, SREBF1, WNT10B |
| Pdx1Lacz/+; Oc1+/− | quantity of endocrine cells | 9.28E-11 | Arx,Gast,Ins,Ins1,Kcnj11,Mafb,Mnx1,Neurog3,Nkx6-1,Pax4,Pax6,Pcsk2 |
| quantity of beta islet cells | 2.40E-10 | Arx,Ins,Ins1,Kcnj11,Mnx1,Nkx6-1,Pax4,Pcsk2 | |
| quantity of alpha islet cells | 2.79E-06 | Arx,Ins,Ins1,Pcsk2 | |
| entry into cell cycle progression of endocrine cell lines | 2.53E-05 | Ins1,SST,TF | |
| concentration of corticosterone | 2.77E-05 | Crhr2,Gck,Glp1r,Ins,Klb,Npy,Scg5 | |
| glucose tolerance | 1.43E-04 | Abcc8,Glp1r,Iapp,Ins,Mafa,Pdx1,Sytl4,Tgfb3 | |
| replication of beta islet cells | 3.55E-04 | Gast,Reg1a | |
| differentiation of endocrine cells | 1.10E-03 | Nkx6-1,Pax4,Pdx1 | |
| area of islets of Langerhans | 1.17E-03 | Ins,Ins1 | |
| differentiation of beta islet cells | 1.17E-03 | Nkx6-1,Pdx1 | |
| regeneration of islet cells | 1.17E-03 | Nkx6-1,Pcsk2 | |
| formation of islet cells | 2.42E-03 | Pax6,Pdx1 | |
| quantity of delta islet cells | 2.42E-03 | Arx,Pcsk2 | |
| synthesis of hormone | 2.88E-03 | Abcc4,Crhr2,Cyp11a1,Ins,Pax6,Vip | |
| proliferation of beta islet cells | 3.98E-03 | Iapp,Ins,Nkx6-1,Pax4 | |
| quantity of enteroendocrine cells | 6.15E-03 | Arx,Pax4 | |
| steroidogenesis of hormone | 7.54E-03 | Abcc4,Crhr2,Cyp11a1,Ins,Vip | |
| size of beta islet cells | 8.60E-03 | Pcsk2,Pdx1 | |
| synthesis of corticosterone | 8.60E-03 | Apoa1,Cyp11a1 | |
| activation of parathyroid gland | 1.09E-02 | Casr | |
| arrest in organogenesis of pancreas | 1.09E-02 | Pdx1 | |
| binding of hypothalamus | 1.09E-02 | Pyy |