Table 2.
Overall Survival
| Variable | Multivariate Adjusted HR (All Patients n = 131) 5% HR 95% | p-value | Multivariate Adjusted HR (Surgical Patients n = 115) 5% HR 95% | p-value |
|---|---|---|---|---|
|
| ||||
| Gender | ||||
| Female | Referent | Referent | ||
| Male | 1.16 2.00 3.45 | 0.012 | 1.47 2.76 5.18 | 0.002 |
|
| ||||
| Age at Surgery | ||||
| <60 years | Referent | Referent | ||
| >60 years | 1.19 2.00 3.34 | 0.009 | 1.41 2.61 4.84 | 0.002 |
|
| ||||
| Metastasis | ||||
| No | Referent | Referent | ||
| Yes | 2.19 4.50 9.23 | <0.001 | 1.88 4.79 12.2 | 0.001 |
|
| ||||
| Surgery | ||||
| R0 Resection | Referent | Referent | ||
| R1 Resection | 0.54 1.02 1.94 | 0.943 | 0.62 1.23 2.46 | 0.553 |
| R2 Resection | 2.80 6.5115.1 | <0.001 | 2.73 6.66 16.2 | <0.001 |
| Unknown (R0 or R1) | 0.51 1.65 5.29 | 0.402 | 0.59 1.92 6.23 | 0.277 |
| No Resection | 3.24 8.24 21.0 | <0.001 | ||
|
| ||||
| Radiation | ||||
| No | Referent | Referent | ||
| Yes | 0.28 0.53 0.99 | 0.046 | 0.28 0.57 1.16 | 0.122 |
|
| ||||
| Chemotherapy | ||||
| No | Referent | Referent | ||
| Yes | 0.38 0.75 1.48 | 0.408 | 0.39 0.91 2.10 | 0.824 |
|
| ||||
| Tumor Size | ||||
| <5 cm | Referent | Referent | ||
| 5 – 15 cm | 0.48 1.32 3.66 | 0.595 | 0.36 1.17 3.75 | 0.789 |
| >15 cm | 0.66 1.74 4.59 | 0.265 | 0.61 1.85 5.61 | 0.277 |
|
| ||||
| Histology | ||||
| WDLPS | Referent | Referent | ||
| DDLPS | 0.70 2.04 5.93 | 0.190 | 0.66 2.02 6.21 | 0.221 |
| LMS | 0.64 1.90 5.62 | 0.246 | 0.72 2.52 8.86 | 0.148 |
| Other | 0.73 2.34 7.55 | 0.154 | 0.65 2.63 10.6 | 0.174 |
|
| ||||
| Grade | ||||
| Low/Intermediate | Referent | Referent | ||
| High | 1.24 2.20 3.87 | 0.007 | 1.06 2.01 3.79 | 0.032 |
| Unknown | 0.87 2.24 5.80 | 0.096 | 0.49 1.76 6.32 | 0.389 |
|
| ||||
| Number of Organs Resected | ||||
| 0 | Referent | |||
| 1–2 | 0.55 1.37 3.43 | 0.498 | ||
| 3–4 | 0.43 1.16 3.10 | 0.770 | ||
| ≥ 5 | 1.73 6.25 22.6 | 0.005 | ||
WDLPS - Well Differentiated Liposarcoma, DDLPS - Dedifferentiated Liposarcoma, LMS - Leiomyosarcoma