Table 1.
Characteristics of the Participants in the Five Studies Included in the Meta-analysis (Number and Percentage Shown for Categorical Variables, Mean and Standard Deviation for Continuous Variables).
| Study | MIGen* | FHS* | FINRISK1997 | FINRISK2002 | EGCUT* |
|---|---|---|---|---|---|
| Design | Case-control | Cohort | Cohort | Cohort | Cohort |
| N | 6,042 | 3,557 | 5,562 | 2,314 | 6,361 |
| Hard IHD events | 2967 | 168 | 367 | 145 | 258 |
| All IHD events | --- | 251 | 447 | 185 | 570 |
| Follow-up, years (SD) | --- | 12.8 (6.2) | 13.8 (2.9) | 9.2 (1.9) | 5.4 (2.4) |
| N women (%) | 1,422 (23.54%) | 1,880 (52.9%) | 2,878 (51.7%) | 1,106 (47.8%) | 3,615 (56.8%) |
| Age, in years | NA* | 54.61 (9.8) | 47.9 (13.3) | 51.7 (12.6) | 48.2 (19.4) |
| SBP*, in mmHg | NA | 125.8 (18.6) | 135.8 (19.7) | 137.9 (20.4) | 128.6 (18.1) |
| DBP*, in mmHg | NA | 74.5 (9.9) | 82.3 (11.3) | 80.2 (11.3) | 78.7 (10.9) |
| BMI*, in kg/m2 | NA | 27.4 (5.0) | 26.6 (4.5) | 27.5 (5.1) | 26.5 (5.2) |
| HTN*, n (%) | NA | 1,020 (28.7%) | 2,477 (44.5%) | 1,143 (49.4%) | 1,771 (27.8) |
| LDL cholesterol*, in mg/dL | NA | 125.1 (34.5) | 134.8 (35.9) | 138.2 (48.7) | 137.3 (40.8)† |
| HDL cholesterol*, in mg/dL | NA | 50.1 (15.1) | 54.8 (13.5) | 58.7 (18.9) | 58.8 (15.9)† |
| Triglycerides, in mg/dL | NA | 139.4 (78.6) | 130.1 (90.3) | 137.2 (92.9) | 139.2 (90.9)† |
| Current Smoking, n (%) | NA | 610 (17.2%) | 1,355 (24.4%) | 617 (26.7%) | 1,904 (29.9%) |
*
MIGen: Myocardial Infarction Genetics Consortium; FHS: Framingham Heart Study; EGCUT: Estonian Biobank; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; BMI: Body mass index; HTN: Hypertension; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; NA: Not available.
†
Data available in a subsample of 3,782 individuals.