. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2016 Apr 21;9(3):279–286. doi: 10.1161/CIRCGENETICS.115.001255

Table 3.

Results of the Improvement in Predictive Capacity when the GRS_LDL and GRS_TG, and the Non-pleiotropic GRS_LDL and GRS_IHD Interaction Terms Were Added to the Model Based on the Individual Genetic Risk Scores: Changes in Discrimination Capacity (δ c-Statistics) and in Reclassification (Continuous Net Reclassification Index –c-NRI– and Integrated Discrimination Improvement –IDI–) for the Two Ischemic Heart Disease Outcomes in the Meta-analyses.

	Hard IHD Outcomes	All IHD Outcomes
GRS_LDL·GRS_TG
δ c-statistic (p-value)	0.000 (0.471)	0.000 (0.217)
c-NRI (95% CI)^*	0.011 (-0.030, 0.052)	0.030 (-0.021, 0.081)
IDI (95% CI)^*	0.000 (-0.001, 0.001)	0.000 (-0.001, 0.002)
Non-pleiotropic GRS_IHD·GRS_LDL
δ c-statistic (p-value)	0.001 (0.263)	0.000 (0.637)
c-NRI (95% CI)^*	0.031 (-0.011, 0.073)	0.029 (-0.019, 0.077)
IDI (95% CI)^*	0.001 (-0.000, 0.001)	0.001 (-0.000, 0.003)

c-NRI (95% CI): Continuous Net Reclassification Index (95% Confidence Interval); IDI (95% CI): Integrated Discrimination Improvement (95% Confidence Interval)