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Increased markers of PLT activation following PAR4 agonist stimulation in Western-diet (WTD)-fed Cdkn2a-deficient strains. Acid-citrate-dextrose whole blood stimulated with PAR4 agonist AYPGKF (100 μM) and analyzed by flow cytometry. A: MFI of PLT surface P-selectin. B: MFI of PLT surface activated form of integrin αIIIbβ3 (JON/A). Kruskal-Wallis (A-B).
