Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Free energy profiles of the two pathways with the lowest barriers for (a.) Thr-In and (b.) Thr-Out simulations, as revealed by zero-temperature string calculations (left side). Overlay of these pathways on selected two-dimensional PMFs (middle and right). The sequential and concurrent pathways are shown in black and orange respectively.
