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. Author manuscript; available in PMC: 2017 Jun 21.
Published in final edited form as: Immunity. 2016 Jun 14;44(6):1271–1283. doi: 10.1016/j.immuni.2016.05.013

Figure 3. Critical role of RelB in suppression of Th17 cells by OX40.

Figure 3

(A and B) Induction of Th17 cells from WT CD4+ T cells transduced with empty vector encoding GFP alone (Ctrl) or with retrovirus expressing p50, RelA, p52, c-Rel, or RelB, and cultured for 3 days under Th17-polarizing conditions (A). Graphs in (B) depict Mean ± SEM of 5 experiments with triplicate cultures. * p <0.05; ** p <0.01.

(C and D) Induction of Th17 cells from WT B6, Nfkb1−/−, Nfkb2−/−, −/−, Nfkb1−/−Nfkb2−/− DKO, and Relb−/− CD4+ T cells activated for 3 days as in Figure 1D(C). Graphs in (D) depict Mean ± SEM of 5 experiments with triplicate cultures. ** p <0.01.