Table 3.

Comparison of the pharmacokinetic parameters (mean ± SD) of the reference (Terramycin LA) and test (Cyamicin LA) formulations at a single dose (20 mg/kg) administration to bovines.

		Terramycin		Cyamicin
Parameter	Unit	Mean	SD	Mean	SD
λ	h−1	0.020	0.005	0.022	0.004
T½λ	h	36.88	11.50	32.61	5.14
Cmax	μg/mL	8.73	3.66	10.43	3.84
Tmax	h	3.58	0.90	3.42	0.51
AUC0–∞	μg h/mL	311.40	93.05	287.71	45.31
AUC0–24	μg h/mL	118.29	45.46	131.15	44.56

λ, rate constant associated with the terminal elimination phase; T½λ, elimination half-life; C_max, maximum concentration; T_max, time to reach maximum concentration; AUC_0–∞, area under the concentration–time curve from 0 to infinity; AUC_0–24, area under the concentration time curve from 0 to 24 h.