Figure 1.

In vivo BLI uses advanced camera imaging systems to visualize live animal subjects as they express bioluminescence from targeted cells and tissues, thereby allowing fundamental biological processes to be monitored non-invasively. Advances in the in vivo BLI field have created luciferase proteins with expanded wavelength emission profiles, stronger and more stable signal generation, substrate-independent real-time expression, and proximity-based expression characteristics that are providing innovative tools for preclinical diagnostics, drug discovery, and toxicology research.