Table 2.
Clinical manifestations of very early-onset inflammatory bowel disease
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 | Patient 9 | Patient 10 | Patient 11 | Patient 12 | Patient 13 | |
| Gender | F | M | M | M | M | M | M | M | M | M | M | F | F |
| Age of onset (mo) | 8 | 1 | 0.3 | 0.3 | 4 | 0.2 | 9 | 2 | 0.5 | 3 | 0.7 | 10 | 36 |
| Height percentile | 19% | 1% | 3% | 1% | 1% | 1% | 52% | 1% | 15% | 1% | 19% | 16% | 20% |
| Weight percentile | 1% | 1% | 1% | 1% | 1% | 20% | 55% | 13% | 8% | 15% | 16% | 60% | 33% |
| Diarrhea (times/d) | > 10 | 7-8 | > 10 | 10 | 5-10 | 5-6 | 7-8 | 2-4 | 7-8 | No diarrhea | 7-8 | No diarrhea | 2-3 |
| Bloody stool | + | + | + | + | + | - | + | + | + | - | + | + | + |
| Infection | Sepsis | Pneumonia | No | Pneumonia, Clostridium difficile infection | Sepsis, oral candidiasis, fungemia, Clostridium difficile infection | Recurrent respiratory infection | No | No | No | Repeated fever of unknow origin | Oral candidiasis, gingivitis | No | No |
| Perianal lesion | Fistulae | No | No | Excrescence | Fistulae, abscess, excrescence | Fistulae, ulcer | No | No | No | No | Fistulae, abscess, excrescence | No | No |
| Clinical diagnosis | CD | CD | CD | CD | CD | CD | CD | CD | UC | CD | CD | UC | UC |
| Medication | GC, 6-MP | IFX, THD | GC, THD | GC, IFX1, THD | GC, IFX, THD | GC, IFX1 | GC, IFX, MES | GC, IFX1, THD, 6-MP | GC, MES | GC, 6-MP, THD | GC, IFX, THD, 6-MP | MES | GC, MES |
| Clinical status | NR | PR | Died at 2 yr because of severe sepsis | PR | Died at 3 yr because of intestinal failure | NR | CR | PR | CR | CR | PR | CR | CR |
1
Allergic to IFX. CD: Crohn's disease; UC: Ulcerative colitis; GC: Glucocorticoid; 6-MP: 6-mercaptopurine; IFX: Infliximab; THD: Thalidomide; MES: Mesalazine; NR: Non-remission; PR: Partial remission; CR: Complete remission.