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. 2016 May 5;7(5):e2212. doi: 10.1038/cddis.2016.110

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Reductions in CTB transport precede cell body loss. (a) Retinas from 48- h post-CTB injection transport experiments were stained with DAPI (blue) and IB4 (magenta) (left panel). Tile scan images of each of the four petals were taken (original magnification= × 10), 0.5mm² areas were selected at 0.5, 2.0 and 3.5mm from the optic nerve (middle panel), and then processed to remove the vascular area from each picture (right panel). DAPI-stained nuclei were counted using ImageJ software. (b) A comparison of DAPI nuclei per mm² revealed no significant differences between IgG₁ or sVEGFR-2 treatments at 0.5, 2.0 or 3.5mm from the optic nerve. These data indicate that at 1-week post-sVEGFR-2 injection, transport deficits may precede significant RGC loss. N=5–6 retinas. Data are given as means±S.E.M.