Figure 1.

Mechanical loading positively regulates bone formation in vivo. (a) GSEA of expression profiles of BMSCs from normal (control) and osteoporosis patients. Enrichment curves computed by GSEA are shown in green (FDR-corrected P<0.05). GSEA for cell cycle checkpoints, Notch signaling pathway, and skeletal development gene sets demonstrated significant enrichment in control human BMSCs as compared with BMSCs from osteoporosis patients. (b) The heat map is ordered by degree of differential expression of Notch signaling pathway and skeletal development genes between BMSCs from normal (control) and osteoporosis patients. (c) Representative microCT reconstructive images of tibial plateau of WB and HU mice. n=6. (d) Three-dimensional microstructural parameters of tibial plateau of WB and HU mice. Data were mean±S.D., *P<0.01. All P-values are based on Student's t-test