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. 2016 May 19;7(5):e2232. doi: 10.1038/cddis.2016.135

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Apoptosis of CD8 T cells correlates with a broad reprogramming of macrophage cytokine responses. (a and b) Infected macrophages and splenic CD8 T cells from infected mice were stimulated or not with soluble anti-CD3 in the presence of interleukin-2 (IL-2). Anti-CD3-activated cocultures were treated or not with anti-FasL or control immunoglobulin G (IgG). After 48 h, culture supernatants were collected for evaluation of NO (a) or cytokine (b) responses, as assessed by a cytokine array. CD8 T cells were analyzed for annexin V/7-AAD (7-aminoactinomycin D) staining (a). Adherent cells were cultured during 4 weeks for determination of released trypomastigotes (a). Data represent mean and S.E.M. of two (b), or three to four (a) technical replicates. Data depicted in (a) represent at least three independent experiments. Significant differences between treatments are indicated (*), as analyzed by analysis of variance (ANOVA) with Bonferroni post-test (a)