Figure 4.

In vivo inhibition of Notch signaling in tumor-bearing mice reduced skeletal muscle atrophy. (a) Notch inhibitor MK-0752 (50 mg/kg) was injected starting two weeks after K7M2 cell injection, three times a week for four weeks. The size of the primary osteosarcoma tumor was unaffected by MK-0752 injection. N = 4 mice in each group. (b) Trichrome staining showing decreased fibrosis formation in muscles with Notch inhibition. (c) Differential myofiber size with and without MK-0752 injection. “∗” in the bar chart indicates P < 0.05.