Figure 6.

The response of thalamic NICE-TC and NICE-RE models to low duty-cycle US stimulation waveforms. The US stimuli (US intensity: 5.2 W/cm²; US frequency: 0.69 MHz; PRF, 100 Hz) are indicated by black bars (A–C). A, B, For a 1.5 s, 5% duty-cycle US stimulus, the TC cell fires a tonic 100 Hz volley of APs, whereas the RE cell fires only one volley and stops. Bottom, The currents' profiles of the segments marked in the top, where I_U is the sum of I_h, $I_{K_L^{+}}$, and I_Leak currents (see complete channel composition in the Theoretical framework section). C, Increasing the duty-cycle to 6% and 7% brings the RE neurons to fire periodical volleys and a constant volley of APs after two braked volleys, respectively. D, The relation between the TC and RE neurons' spike rates and the US stimulation duty-cycle, calculated for the last 0.5 s period of the 1.5-s-long US stimulation.