Table 6.
Post hoc Bayesian estimates of pharmacokinetic parameters and derived secondary parameters for piperaquine and azithromycin in pregnant Papua New Guinean women. Data are median [interquartile range]
| Parameter | Piperaquine | Azithromycin |
|---|---|---|
| MTT (h) | 3.29 [3.29–3.29] | − |
| NN | 1.425 [1.331–1.610] | − |
| k a | − | 0.93 [0.93–0.93] |
| DUR | − | 1.60 [1.29–1.93] |
| CL/F ( l h −1 ) | 75.9 [65.9–83.3] | 64.1 [60.7–68.9] |
| V C /F (l) | 1457 [1122–2013] | 354 [152–628] |
| Q 1 /F ( l h −1 ) | 56.9 [54.5–61.4] | 199 [191–215] |
| V P1 /F (l) | 13 758 [12 994–15 223] | 1837 [1735–2033] |
| Q 2 /F ( l h −1 ) | 227 [217–244] | 56.9 [54.5–61.4] |
| V P2 /F (l) | 2868 [2709–3174] | 3242 [3062–3587] |
| t ½ α (h) | 2.33 [1.88–2.77] | 0.738 [0.316–1.210] |
| t ½ β (h) | 28 [27.5–28.8] | 15.5 [14.9–16.1] |
| t ½ γ (h) | 315 [303–331] | 89.2 [86.1–93.0] |
| C max (μg l −1 ) | 731 [445–900] | 1080 [839–1,439] |
| AUC 0‐∞ (μg h l −1 ) | 38 818 [24 354–52 299] | 46 799 [43 526–49 462] |
| AUC 0‐∞ (μg h l −1 ) per mg kg −1 dose | 1264 [846–1873] | 846 [828–876] |
AUC0–∞, area under the plasma concentration–time curve; CL/F, clearance; Cmax, maximum plasma concentration; MTT, mean transit time; NN, number of transit compartments; Q1/F, intercompartmental clearance for VP1/F; Q2/F, intercompartmental clearance for VP2/F; t½ α, t½ β and t½ γ, first and second distribution, and elimination half‐lives, respectively; VC/F, central volume of distribution; VP1/F, first peripheral volume of distribution; VP2/F, second peripheral volume of distribution.