Table 2.

Odds Ratios (OR) and 95% confidence intervals (95% CI) of acute serious liver injury associated with NSAIDs (sex and age related analysis)

Drug	No. (%) of cases	No. (%) of controls	OR (95% CI)	OR Adg (95% CI) †
NSAIDs *	97 (54)	737 (42)	1.71 (1.23–2.36)	1.69 (1.21–2.37)
Sex
Male	43 (44)	306 (42)	1	1
Female	54 (56)	431 (58)	0.89 (0.57–1.40)	0.71 (0.42–1.19)
Age
<45	46 (47)	293 (40)	1	1
45–65	29 (30)	225 (30)	0.82 (0.48–1.38)	1.21 (0.66–2.20)
>65	22 (23)	219 (30)	0.64 (0.36–1.12)	0.75 (0.36–1.56)

^* NSAIDs with at least one case included nimesulide, acetylsalicylic acid (ASA), ibuprofen, ketoprofen, diclofenac, celecoxib, etoricoxib, naproxen, flurbiprofen, piroxicam, indomethacin, and dexibuprofen.

^† See methods sections for details of adjustment.