Table 3.
Odds ratios (OR) and 95% confidence intervals (95% CI) of acute serious liver injury associated with all NSAIDs and paracetamol
| Drug (prevalence of use) | No. (%) of cases | No. (%) of controls | OR (95% CI) | OR Adg (95% CI) * |
|---|---|---|---|---|
| ASA (13.5) | 31 (17) | 253 (14) | 1.30 (0.85–2.00) | 1.54 (0.95–2.48) |
| Nimesulide (11.1) | 30 (17) | 184 (10) | 1.88 (1.20–2.95) | 2.10 (1.28–3.47) |
| Ketoprofen (10.7) | 19 (11) | 177 (10) | 0.98 (0.57–1.68) | 1.10 (0.60–2.00) |
| Ibuprofen (8.1) | 25 (14) | 170 (10) | 1.59 (0.98–2.57) | 1.92 (1.13–3.26) |
| Diclofenac (5.1) | 12 (7) | 85 (5) | 1.48 (0.77–2.84) | 1.50 (0.74–3.06) |
| Paracetamol (16.7) | 69 (39) | 309 (17) | 3.27 (2.32–4.59) | 2.97 (2.09–4.21) |
*
See methods sections for details of adjustment.