Table 5.

Odds ratios (OR) and 95% confidence intervals (95% CI) of acute serious liver injury associated with different doses of NSAIDs and paracetamol

DRUG Dose	No. (%) of cases	No. (%) of controls	OR (95% CI)	OR Adg (95% CI) †
NIMESULIDE
<200 mg	21 (11.73)	172 (9.72)	1.41 (0.85–2.35)	1.55 (0.89–2.70)
≥200 mg	9 (5.03)	12 (0.68)	8.03 (3.36–9.22)	10.69 (4.02–28.44)
ASA
<300 mg	21 (11.73)	168 (9.49)	1.35 (0.80–2.27)	1.46 (0.82–2.58)
≥300 mg	10 (5.59)	85 (4.80)	1.22 (0.62–2.43)	1.70 (0.81–3.54)
KETOPROFEN
<150 mg	10 (5.62)	142 (8.02)	0.67 (0.34–1.34)	0.73 (0.35–1.54)
≥150 mg	8 (4.49)	19 (1.07)	3.29 (1.35–8.04)	4.65 (1.33–10.00)
IBUPROFEN
<1200 mg	20 (11.24)	155 (8.76)	1.45 (0.86–2.43)	1.71 (0.97–3.02)
≥1200 mg	4 (2.23)	15 (0.85)	2.62 (0.82–8.32)	3.73 (1.11–12.46)
DICLOFENAC
<100 mg	5 (2.79)	30 (1.69)	1.69 (0.64–4.48)	2.13 (0.77–5.91)
≥100 mg	3 (1.68)	25 (1.41)	1.19 (0.35–4.09)	1.21 (0.30–4.85)
PARACETAMOL
<3000 mg	42 (23.46)	265 (14.97)	2.22 (1.48–3.15)	2.04 (1.35–3.09)
≥3000 mg	I26 (14.52)	I44 (2.49)	I7.80 (4.53–13.43)	I6.31 (3.56–11.20)

^† See methods sections for details of adjustment