Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 25;82(1):185–198. doi: 10.1111/bcp.12934

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Simulated mid‐dose concentrations across weight‐bands (left) and by different 516GT|983TC genotypes (right) based on dose recommendations tested in IMPACT study P1070 applied to our population. Red horizontal lines correspond to efavirenz concentrations of 1 mg l⁻¹ and 4 mg l⁻¹ 3. Breaks in the percentile plot correspond to 25th, median and 75th percentile and whiskers correspond to 5th and 95th percentile of the simulated data. CYP2B6 () 516GG|983TT; () 516GG|983TC; () 516GG|983CC; () 516GT|983TT; () 516GT|983TC; () 516TT|983TT

Inline graphic — Simulated mid‐dose concentrations across weight‐bands (left) and by different 516GT|983TC genotypes (right) based on dose recommendations tested in IMPACT study P1070 applied to our population. Red horizontal lines correspond to efavirenz concentrations of 1 mg l⁻¹ and 4 mg l⁻¹ 3. Breaks in the percentile plot correspond to 25th, median and 75th percentile and whiskers correspond to 5th and 95th percentile of the simulated data. CYP2B6 () 516GG|983TT; () 516GG|983TC; () 516GG|983CC; () 516GT|983TT; () 516GT|983TC; () 516TT|983TT