Table 1.
Demographic characteristics
| Characteristics | ARROW | CHAPAS‐3 | Combined | |
|---|---|---|---|---|
| iPK | iPK | sPK | ||
| No. of children * | 41 | 51 | 128 | 169 |
| No. of samples | 611 | 474 | 1002 | 2087 |
| Sampling schedule | 0 h, 1 h, 2 h, 4 h, 6 h, 8 h, 12 h, 24 h | 2 samples 2 h apart | ||
| No. of samples excluded | 9 | 8 | 5 | 22 |
| Age (years) ** | 7.6 (4.0–12.5) | 4.5 (2.1–13.8) | 4.7 (2.1–13.8) | |
| Weight (kg) ** | 20.0 (14.0–30.0) | 15.0 (7.8–29.9) | 15.5 (7.8–30.0) | |
| Sex (M/F) | 17/24 | 63/65 | 80/89 | |
| Race | Black African | |||
| CYP2B6 516GT (rs3745274; HWE P = 1) † | ||||
| GG | 16 (44%) | 49 (39%) | 65 (40%) | |
| GT | 14 (39%) | 53 (42%) | 67 (41%) | |
| TT | 6 (17%) | 24 (19%) | 30 (19%) | |
| MAF | 0.36 | 0.40 | 0.39 | |
| CYP2B6 983T>C (rs28399499; HWE P = 0.6) † | ||||
| TT | 33 (92%) | 106 (84%) | 139 (86%) | |
| TC | 3 (8%) | 19 (15%) | 22 (14%) | |
| CC | 0 (0%) | 1 (1%) | 1 (1%) | |
| MAF | 0.04 | 0.08 | 0.07 | |
| CYP2B6 15582C>T (rs4803419; HWE P = 1) † | ||||
| CC | 32 (89%) | 113 (90%) | 145 (90%) | |
| TC | 4 (11%) | 13 (10%) | 17 (10%) | |
| MAF | 0.06 | 0.05 | 0.05 | |
| CYP3A4*22 (rs35599367) † | ||||
| GG | 36 (100%) | 126 (100%) | 162 (100%) | |
| CYP3A5 6986G>A (rs776746; HWE P = 0.57) † | ||||
| GG | 1 (3%) | 2 (2%) | 3 (2%) | |
| GA | 7 (19%) | 41 (33%) | 48 (30%) | |
| AA | 28 (78%) | 83 (66%) | 111 (69%) | |
| MAF | 0.12 | 0.18 | 0.17 | |
| NR1I3 (rs3003596; HWE P = 0.34) † | ||||
| AA | 7 (19%) | 30 (24%) | 37 (23%) | |
| AG | 18 (50%) | 55 (44%) | 73 (45%) | |
| GG | 11 (31%) | 41 (33%) | 52 (32%) | |
| MAF | 0.46 | 0.46 | 0.46 | |
| NR1I3 540 C>T (rs2307424; HWE P = 1) † | ||||
| TT | 0 | 1 (1%) | 1 (1%) | |
| CT | 3 (8%) | 23 (18%) | 26 (16%) | |
| CC | 33 (92%) | 102 (81%) | 135 (83%) | |
| MAF | 0.04 | 0.10 | 0.09 | |
| NR1I2 63396C>T (rs2472677; HWE P = 0.07) † | ||||
| CC | 13 (36%) | 43 (34%) | 56 (35%) | |
| CT | 16 (44%) | 72 (57%) | 88 (54%) | |
| TT | 7 (19%) | 11 (9%) | 18 (11%) | |
| MAF | 0.42 | 0.37 | 0.38 | |
| CYP2B6*4 785A>G (rs2279343; HWE P = 0.47) ‡ | ||||
| AA | 16 (44%) | |||
| AG | 14 (39%) | not tested | ||
| GG | 6 (17%) | |||
| MAF | 0.36 | |||
| CYP2B6 499C>G (rs3826711) ‡ | ||||
| CC | 36 (100%) | not tested | ||
| CYP2B6*29 ‡ | ||||
| *1 /*1 | 36 (100%) | not tested | ||
Data are median (range) or no. (%) of subjects.
*
51 children in the CHAPAS‐3 study who underwent both intensive and sparse sampling are counted in both categories.
**
Baseline values.
†
162 pts from both CHAPAS‐3 and ARROW studies.
‡
36 pts from ARROW study. HWE, Hardy–Weinberg equilibrium; iPK, intensive sampling; MAF, minor allele frequency; sPK, sparse sampling.