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. 2016 May 2;82(1):178–184. doi: 10.1111/bcp.12930

Table 3.

Final pharmacokinetic–pharmacodynamic model parameter estimates. Bootstrap results are presented as mean and 95% confidence interval (CI)

Parameter Covariate model Parameter estimate Bootstrap (95% CI)
θCL (l h −1 15 kg −1 ) CL = θCL × FFM/15 0.603*
ωCL(%) 50*
θV (l 20 kg −1 ) V = θV × WT/20 0.751*
ωV(%) 40*
Corr(CL, V) 0.745*
θD1(h) 0.1*
θE0(s) 35.6 35.6 (34.6, 36.7)
ωE0(%) 0.43 0.44 (0.38, 0.51)
θSLP 0.67 0.67 (0.58, 0.78)
ωSLP(%) 64 63 (50, 76)
σprop(%) 30 30 (26, 33)
σadd (U l −1) 0.005 0.005 (0.001, 0.012)

aPTT, activated partial thromboplastin time; Corr(CL, V) , correlation between heparin clearance and volume of distribution; E0, baseline aPTT in s; SLP, slope of the linear model; θ, mean value of the fixed‐effect parameter; ω, between‐subject variability (presented as coefficient of variation percentage, CV%); σprop proportional component of the residual variability (presented as CV%); σadd , additive component of the residual variability (presented as standard deviation).

*

Values fixed.