Table 3.
Final pharmacokinetic–pharmacodynamic model parameter estimates. Bootstrap results are presented as mean and 95% confidence interval (CI)
| Parameter | Covariate model | Parameter estimate | Bootstrap (95% CI) |
|---|---|---|---|
| θCL (l h −1 15 kg −1 ) | CL = θCL × FFM/15 | 0.603* | |
| ωCL(%) | 50* | ||
| θV (l 20 kg −1 ) | V = θV × WT/20 | 0.751* | |
| ωV(%) | 40* | ||
| Corr(CL, V) | 0.745* | ||
| θD1(h) | 0.1* | ||
| θE0(s) | 35.6 | 35.6 (34.6, 36.7) | |
| ωE0(%) | 0.43 | 0.44 (0.38, 0.51) | |
| θSLP | 0.67 | 0.67 (0.58, 0.78) | |
| ωSLP(%) | 64 | 63 (50, 76) | |
| σprop(%) | 30 | 30 (26, 33) | |
| σadd (U l −1) | 0.005 | 0.005 (0.001, 0.012) |
aPTT, activated partial thromboplastin time; Corr(CL, V) , correlation between heparin clearance and volume of distribution; E0, baseline aPTT in s; SLP, slope of the linear model; θ, mean value of the fixed‐effect parameter; ω, between‐subject variability (presented as coefficient of variation percentage, CV%); σprop proportional component of the residual variability (presented as CV%); σadd , additive component of the residual variability (presented as standard deviation).
*
Values fixed.