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. 2016 Apr 7;82(1):83–91. doi: 10.1111/bcp.12917

Figure 3.

Figure 3

Pharmacokinetic–pharmacodynamic analysis (inhibitory E max model) of the d‐nebivolol isomer as a function of heart rate variation induced by isometric handgrip exercise in all patients classified as extensive metabolizers of cytochrome P450 2D6 (n = 43), E max, maximum heart rate variation